If you’re a beginning a weight training program, or you want to maintain (rather than gain) muscle size and strength, then you’ll probably notice little difference between single and multiple sets. And, if you only have a limited amount of time to spend in the gym, then one set is better than no sets.
If, however, you’ve been training for some time, a multiple-set program will deliver faster results than a program using single sets, whether you’re training for muscle size or muscle strength.
Multiple sets are also superior to single sets in weight training routines designed for fat loss. Not only do multiple sets increase the total number of calories burned during exercise, testosterone and growth hormone levels, both of which aid fat loss and muscle growth tend to be greater following multiple rather than single sets. The only thing I recommend is train hard and intense, but no more than 60 minutes in any one day for those looking to pack on muscle.
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